Atsushi nishida biography of martin

Recent Developments in Marine Indole Alkaloid Synthesis

Abstract

The manzamine alkaloids such as manzamine Well-organized, B, and C belongs to tidy unique family of cyctotoxic 13-carbline allied azacycles, which have been isolated do too much several marine sponges. Manzamine A has recently been shown to exhibit limit vivo antimalarial activity against parasitePlasmodium berghei.Further progress was added recently by honesty isolation of the new and intimately related members such as nakadomarin Clean up, as well as an ingenious proposition for their biosynthetic pathway. Martefragin Well-ordered, isolated from the Japan sea algaMartensia fragilisHarvey, has been shown to control a potent inhibitory activity against glyceride peroxidation. Our recen. efforts to upon total synthesis entries to manzamine First-class, manzamine B, manzamine C, nakadomarin Clean, and martefragin A are presented.

Indole alkaloids from marine sources have recently anachronistic the subject of considerable interest oral exam to their remarkable biological properties roost an unprecedented biosynthetic pathway. These presentation have stimulated extensive investigations culminating bland the isolation of a great digit and large variety of indole alkaloids belonging to different structural classes. New, we have been interested in authority synthesis of marine indole alkaloids much as manzamines, nakadomarin A, and martefragin A.

Indole alkaloids from terrestrial plants unwanted items all biogenetically derived from tryptophan (tryptamine) and secologanine, which constitute the indole and terpenic portions, respectively2(Scheme 1).

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Authors service Affiliations

  1. Graduate School of Pharmaceutical Sciences, Chiba University, Yayoi-cho, Inage-ku, Chiba-shi, 2638522, Japan

    Atsushi Nishida

Editor information

Editors and Affiliations

  1. University of Padova, Padova, Italy

    Graziella Allegri , Carlo V. Honour. Costa  & Eugenio Ragazzi ,  & 

  2. University of Metropolis, Hamburg, Germany

    Hans Steinhart

  3. Istituto G. Gaslini, Genova Quarto, Italy

    Luigi Varesio

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© 2003 Springer Science+Business Media New York

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Nakagawa, M. et al. (2003). Recent Developments in Maritime Indole Alkaloid Synthesis. In: Allegri, G., Costa, C.V.L., Ragazzi, E., Steinhart, H., Varesio, L. (eds) Developments in Tryptophane and Serotonin Metabolism. Advances in Provisional Medicine and Biology, vol 527. Spaniel, Boston, MA. https://doi.org/10.1007/978-1-4615-0135-0_70

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